The quadruple marker test in Delhi — along with the triple marker test — is a second-trimester blood test that screens your baby for Down syndrome, Edwards syndrome and neural tube defects such as spina bifida. Done between 15 and 20 weeks, it is especially useful if you missed the first-trimester screening. At Edge Imaging & Diagnostics in Paschim Vihar, West Delhi, the triple and quadruple marker tests are offered as part of accurate, well-guided pregnancy screening.
This guide explains what the triple and quadruple marker tests are, when they are done, the difference between them, and what the results mean.
Reviewed by Dr. Nishant Thapar, MBBS, MD (Radiodiagnosis), Founder — Edge Imaging & Diagnostics, Paschim Vihar, New Delhi.
What Are the Triple and Quadruple Marker Tests?
Both are maternal blood tests done in the second trimester (also called maternal serum screening). They measure substances produced by the baby and placenta, and — adjusted for your age and pregnancy details — estimate the chance of certain conditions. The triple marker test measures three markers (AFP, hCG and estriol). The quadruple (quad) marker test measures a fourth marker as well (inhibin-A), which makes it more accurate. Like all screening tests, they estimate risk rather than give a definite diagnosis.
When Is the Test Done?
The triple and quadruple marker tests are done between 15 and 20 weeks of pregnancy, ideally around 16–18 weeks. This is later than the first-trimester double marker test and NT scan, which is why the quad test is often the right choice for mothers who came for their first check after the first trimester.
What Do They Screen For?
- Down syndrome (Trisomy 21)
- Edwards syndrome (Trisomy 18)
- Neural tube defects such as spina bifida and anencephaly (through the AFP marker)
The neural tube (spine) screening is a useful extra that the first-trimester tests do not provide, and it is complemented by the detailed anomaly scan.
Triple vs Quadruple Marker — Which Is Better?
The quadruple marker test is generally preferred because the extra marker (inhibin-A) improves its detection rate for Down syndrome compared with the triple test, with fewer false alarms. Your doctor will advise which is suitable for you; where available, the quad test is the more accurate second-trimester option.
| Test | Markers measured | Timing |
|---|---|---|
| Triple marker | AFP, hCG, estriol | 15–20 weeks |
| Quadruple marker | AFP, hCG, estriol, inhibin-A | 15–20 weeks |
Understanding Your Results
Results are reported as a risk ratio (for example 1 in 1,000) and as screen-positive or screen-negative. A screen-negative (low-risk) result is reassuring. A screen-positive (high-risk) result does not mean your baby has the condition — it means further testing can be offered, such as NIPT, or a diagnostic test like amniocentesis, along with counselling for clear guidance.
Is the Test Safe?
Completely. It is a simple blood sample from your arm, with no risk to you or your baby. Usually no fasting is needed, and results are available within a few days.
Quadruple Marker Test in Delhi — Why Choose Edge Imaging
At Edge Imaging & Diagnostics, the triple and quadruple marker tests are offered by Dr. Nishant Thapar‘s team with accurate reporting and, where needed, coordination with your anomaly scan — all under our NABH-aligned quality standards. Expectant mothers across West Delhi — Paschim Vihar, Punjabi Bagh, Rajouri Garden, Moti Nagar and nearby areas — trust our reliable, patient-first prenatal care. To book a quadruple marker test in Delhi, call 9555999960 or visit our contact page.
Frequently Asked Questions
How much does the quadruple marker test cost in Delhi?
The triple or quadruple marker test in Delhi generally costs about ₹1,500–₹3,000. Edge Imaging offers transparent pricing — please call us for the current cost.
Do I need to fast for the test?
Usually no fasting is required. It is a simple blood test; any instructions will be shared when you book.
What is the difference between the triple and quadruple marker test?
The quadruple test measures one extra marker (inhibin-A) than the triple test, which makes it more accurate for Down syndrome screening with fewer false positives.
I missed my first-trimester screening — can I still be screened?
Yes. The quadruple marker test between 15 and 20 weeks is the recommended option if the first-trimester NT scan and double marker window has passed.
What does a screen-positive result mean?
It means the estimated chance is above the cut-off, not that your baby has the condition. Confirmatory tests such as NIPT or amniocentesis can give a definite answer.
Where can I get a quadruple marker test near me in West Delhi?
Edge Imaging & Diagnostics in Paschim Vihar offers the triple and quadruple marker tests for patients across West Delhi. Call 9555999960 to book.
Book Your Triple / Quadruple Marker Test in Delhi
Second-trimester screening gives valuable reassurance. Book an accurate quadruple marker test in Delhi at Edge Imaging & Diagnostics between 15 and 20 weeks. Call 9555999960 to schedule.
Disclaimer: This article is for general information and patient awareness only and does not replace a consultation with a qualified doctor. Screening choice and interpretation depend on your individual pregnancy. For trusted patient information on Down syndrome and neural tube screening, see the NHS screening guide.